E627 Disodium Guanylate

E627Flavor enhancersOrigin: Plant or animal

Get a personal answer

Pick your family’s diets in the bar above.

Every diet

VeganDepends

Usually from yeast, sometimes fish. Look for a vegan label.

Gluten-freeYes

HalalDepends

Depends on the source.

KosherDepends

Depends on the source.

KetoYes

Low-FODMAPYes

The short answer

Disodium guanylate (E627) is a savory booster used with MSG. It's usually made from yeast, but can come from fish, so check for a vegan label.

86/100

Generally safe

Fine for most people at normal amounts.

E-numberE627

Comes fromPlant or animal

What it doesFlavor enhancers

Glycemic index—

Daily limitNot set

Also calledDisodium guanylate, Sodium guanylate

Rules by country

🇺🇸 US FDAApproved

🇪🇺 European UnionApproved

🇨🇦 Health CanadaApproved

CaliforniaNo extra rules

Approved everywhere with no numerical daily limit.

Daily limit: Experts haven’t set a number because normal food amounts are far below any level of concern.

What is it?

Guanylate is a nucleotide naturally found in dried mushrooms. Like inosinate, it amplifies glutamate's savory taste.

Where it comes from: Usually made from yeast or by fermentation; it can also come from dried fish.

Why it’s in food

Boosts savory flavor
Lets makers use less MSG

Often found in

ChipsInstant noodlesSoupsSeasonings

Also listed as: Disodium guanylate, Sodium guanylate, GMP

Health & gut impact

GoutUnder study

A purine; people with gout may want to limit it.

EFSA (2010)

What can I use instead?

Dried shiitake powder

Ratio: To taste

Best for: Savory dishes

More flavor enhancers:

Disodium Inosinate E631Disodium inosinate (E631) boosts savory flavor, usually alongside MSG. It's often made by fermentation but can come from meat or fish, so it's only reliably vegan when labeled.Generally safe Monosodium Glutamate (MSG) E621MSG (E621) is a fermented seasoning with the same glutamate found in tomatoes and parmesan. It's vegan, gluten-free and considered safe; studies haven't confirmed the "MSG headache."Generally safe

Common questions

Is Disodium Guanylate safe?

Generally safe (86/100). Approved everywhere with no numerical daily limit.

Is Disodium Guanylate vegan?

Depends. Usually from yeast, sometimes fish. Look for a vegan label.

Is Disodium Guanylate gluten-free?

Yes.

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Scientific sources & regulatory citations

21 CFR 172.530 (US FDA)
EFSA OpenFoodTox: E627
EFSA (2010)

Last checked against FDA, EFSA and Health Canada records: October 31, 2026 · INS 627 · CAS 5550-12-9