My diet:
Comparison

Nisin vs Natamycin

The short answer
They do different jobs, so cheese often uses both. Nisin stops bacteria, natamycin stops mold. Nisin is the less controversial of the two, because natamycin is also used as a medicine.
Side by sideNisinNatamycin
Safety score86/100 Generally safe74/100 Use in moderation
StopsBacteria and their sporesMold and yeast
Made byLactococcus lactis (cheese bacteria)Streptomyces natalensis (soil bacteria)
Used in medicineNo ✓ BetterYes, for fungal eye infections
Where it's usedMixed into processed cheese and puddingsOn cheese rinds and sausage casings
VeganDepends on the growth mediumYes ✓ Better
Safety score86 ✓ Better74

Swapping one for the other

Buy block cheese and grate it yourself, store it wrapped in cheese paper, and cut off any rind. You'll avoid most of both.

Common questions

Are nisin and natamycin antibiotics?

Both are made by bacteria and fight microbes. Only natamycin is also used as a medicine.