My diet:
Comparison

Aspartame vs Sucralose

The short answer
Both are approved with open questions. Sucralose is heat-stable for baking; aspartame isn't, and it must be avoided by people with PKU.
Side by sideAspartameSucralose (Splenda)
Safety score55/100 Use in moderation60/100 Use in moderation
Brand namesNutraSweet, EqualSplenda
BakingBreaks downHeat-stable ✓ Better
PKU warningYesNo ✓ Better
2023 cancer classificationPossibly carcinogenic (2B)Not classified ✓ Better
Gut bacteria questionsSomeSome

Swapping one for the other

Neither swaps 1:1 with sugar by volume. Use the conversion chart on the packet.

Common questions

Which is safer?

Both are within limits at normal use. If you're cautious, stevia and monk fruit have fewer open questions.